Hi! I am Angli Xue, a PhD candidate at Program in Complex Trait Genomics (PCTG) group at University of Queensland, Australia. I am interested in dissecting the genetic architecture of human complex diseases, performing meta-analysis and integrating multi-omics data to identify associated gene loci and gene regulating mechanisms.
I’m currently working at Prof. Jian Yang’s laboratory, and my PhD thesis topic is “identification of genetic and modifiable risk factors for complex traits and diseases”.
Overview
Angli Xue is a PhD student at Institute for Molecular Bioscience (IMB), The University of Queensland (UQ). He received his bachelor in 2015 from Zhejiang University (ZJU), China, which was followed by a one-year research assistant at the Institute of Bioinformatics, ZJU. He joined Program in Complex Trait Genomics (PCTG) group at UQ in 2016. His research interests are in dissecting the genetic architecture of human complex diseases, performing meta-analysis and integrating multi-omics data to identify associated gene loci and gene regulating mechanisms.
Research focuses
Genetic architecture of complex traits and diseases (e.g. type 2 diabetes, skin cancer, substance use, Parkinson’s disease)
Integrative analyses of multi-omics data (e.g. SNP, gene expression, DNA methylation and histone modification)
Genetic correlation among substance and behavioural addiction (e.g. smoking, alcohol consumption and cannabis use)
Causal association between addictive behaviours/physical activities and common diseases/socio-economic status
X chromosome inactivation (e.g. dosage compensation model)
Qualifications
PhD in Statistical Genetics, The University of Queensland, 2016 - 2021
Bachelor in Agronomy, Zhejiang University, 2011 - 2015
Selected Publications
Angli Xue, Yang Wu, Zhihong Zhu, Futao Zhang, Kathryn E Kemper, Zhili Zheng, Loic Yengo, Luke R. Lloyd-Jones, Julia Sidorenko, Yeda Wu, eQTLGen Consortium, Allan F McRae, Peter M Visscher, Jian Zeng, Jian Yang. Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. Nature Communications. 2018. 9 (1), 1-14.
Angli Xue, Hongcheng Wang, Jun Zhu. Dissecting genetic architecture of complex trait using multi-omics information: A case of association mapping for startle response in Drosophila melanogaster. Scientific Reports. 2017. 7 (1), 1-7.
Preprint
Genome-wide analyses of behavioural traits biased by misreports and longitudinal changes
Angli Xue, Longda Jiang, Zhihong Zhu, Naomi R. Wray, Peter M. Visscher, Jian Zeng, Jian Yang. Genome-wide analyses of behavioural traits biased by misreports and longitudinal changes. Under review. 2020.
Jian Zeng, Angli Xue, Longda Jiang, Luke R Lloyd-Jones, Yang Wu, Huanwei Wang, Zhili Zheng, Loic Yengo, Kathryn E Kemper, Naomi R Wray, Peter M Visscher, Jian Yang. Bayesian analysis of summary data reveals differential signatures of natural selection across human complex traits and functional genomic regions. Under review. 2020.
A work by Angli Xue